Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Caspase-3' and Ligand = 'BDBM10351'
TargetCaspase-3(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataKi:  4.40nM IC50: 3.90nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40SDNPubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 3.89nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VTJPubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataEC50:  450nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB176GPubMed