Compile Data Set for Download or QSAR
Found 9 Enz. Inhib. hit(s) with Target = 'Cathepsin K' and Ligand = 'BDBM50095491'
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataKi:  140nMAssay Description:Inhibitory constant of the compound against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory activity tested against Human Cathepsin K receptor using gelatinase assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory constant of the compound against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory activity tested against Human Cathepsin K using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 7.0Assay Description:Inhibition of Cathepsin K at pH 7More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 60nMpH: 5.5Assay Description:Inhibition of Cathepsin K at pH 5.5More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 90nMpH: 5.5Assay Description:Effect of 10 mM of GSH on the inhibitory activity of compound against Cathepsin K, at pH 5.5More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 150nMpH: 7.0Assay Description:Effect of 10 mM of GSH on the inhibitory activity against Cathepsin K, at pH 7More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibitory activity tested against Human Cathepsin K receptor using bone resorption assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed