Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Cellular tumor antigen p53' and Ligand = 'BDBM50229787'
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GRQPubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GRQPubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 7.10E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75HGJPubMed