Compile Data Set for Download or QSAR
Found 25 Enz. Inhib. hit(s) with Target = 'Cholinesterase' and Ligand = 'BDBM10620'
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant butyrylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q218379RPubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human BChE by Ellman methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22V2HQ7PubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of BuChEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M37S1PubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75DJ6PubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6933PubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibitory concentration against human plasma ButyrylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TM7BWQPubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of BChEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6CH9PubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of BChE in human serum assessed as hydrolysis of butyrylthiocholine by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40V8PPubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 179nMAssay Description:Inhibition of purified human plasma BuChE preincubated for 30 mins before DTNB substrate addition by spectrophotometric assay based Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ3300PubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of BuChE (unknown origin) using butyrylthiocholine iodide as substrate incubated for 25 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474CNVPubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of butyrylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3NTHPubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of human serum BuchE after 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52PFQPubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 301nMAssay Description:Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 90 mins before substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0GJBPubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 301nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2668BD3PubMedDrugBank
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 301nMAssay Description:Inhibition of human serum recombinant BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2WXVPubMedDrugBank
TargetCholinesterase(Equus caballus (Horse))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 499nMAssay Description:Inhibition of equine serum butyrylcholine esterase incubated for 15 mins using S-butyrylthiocholine chloride substrate by colorimetric Ellman's metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959K85PubMed
TargetCholinesterase(Equus caballus (Horse))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 832nMAssay Description:Inhibition of horse serum BChE preincubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP47CJPubMed
TargetCholinesterase(Equus caballus (Horse))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of equine serum BChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 15...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5Q18PubMed
TargetCholinesterase(Mus musculus (Mouse))
Fudan University

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of mouse serum BChEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B4GPubMed
TargetCholinesterase(Equus caballus (Horse))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMpH: 8.0 T: 2°CAssay Description:All the assays were under 0.1 M KH2PO4/K2HPO4 buffer, pH 8.0, using a Shimadzu 2450 Spectrophotometer. Enzyme solutions were prepared to give 2.0 uni...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29022NHPubMed
TargetCholinesterase(Equus caballus (Horse))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of equine serum BChE using butylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03ZDPubMed
TargetCholinesterase(Equus caballus (Horse))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of equine serum BChE using BTC as substrate preincubated for 15 mins followed by substrate addition measured at 1 min intervals by Ellman ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP4801PubMed
TargetCholinesterase(Equus caballus (Horse))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of equine BChE using after 10 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V989F2PubMed
TargetCholinesterase(Equus caballus (Horse))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.84E+4nMAssay Description:Inhibition of equine serum BChE by spectrophotometric-based Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4MPWPubMed
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of BChEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73DBZPubMedDrugBank