TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Binding affinity against Dopamine receptor D2 in rat striatal membranes using [3H]spiperoneMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 70nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2 short receptor expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 70nMAssay Description:Displacement of [3H]spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 70nMAssay Description:Displacement of [3H]spiperone from human dopamine D2S receptor transfected in CHO cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 260nMAssay Description:Displacement of [3H]spiperone from human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 260nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2 long receptor expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 260nMAssay Description:Displacement of [3H]spiperone from human dopamine D2L receptor transfected in CHO cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataKi: 2.95E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 4.32E+3nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D2 trunk/D2 tail receptor transfected in african green monkey COS7 cel...More data for this Ligand-Target Pair
Affinity DataIC50: 4.78E+3nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 8.20nMAssay Description:Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 148nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 39nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 353nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET a...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 270nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincu...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 r...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 52nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 360nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cell membranes co-expressing PTX insensitive variant of Galphao1 incubated for 30 mins by [35S]GTP...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293T cells assessed as reduction in forskolin-induced cAMP accumulation preincubated f...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 73nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cells incubated for 5 hrs by beta-Arrestin 2 recruitment assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Partial agonist activity at human Gi/o-coupled D2R expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 2.70nMAssay Description:Partial agonist activity at D2L receptor (unknown origin) expressed in human HTLA cells assessed as beta-arrestin2 recruitment after 20 to 22 hrs by ...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 115nMAssay Description:Partial agonist activity at human D2L receptor expressed in HEK293T cells co-expressing N-terminal venus-tagged beta-arrestin2 assessed as beta-arres...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 2.70nMAssay Description:Partial agonist activity at D2L receptor (unknown origin) expressed in human HTLA cells assessed as beta-arrestin2 recruitment after 20 to 22 hrs by ...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 2.40nMAssay Description:Partial agonist activity at human D2L receptor expressed in HEK293T cells co-expressing Galpahi1/Gbeta1/GFP2-Ggamma2 assessed as Galphai1 dissociatio...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Partial agonist activity at human Gi/o-coupled D2R expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 150nMAssay Description:Agonist activity at human D2S receptor expressed in CHOK1 cells assessed as inhibition of forskolin induced cAMP production preincubated for 10 mins ...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 151nMAssay Description:Agonist activity at human D2S receptor expressed in CHOK1 cells assessed as inhibition of forskolin induced cAMP production preincubated for 10 mins ...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at D2R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 5.10nMAssay Description:Agonist activity at human D2R isoform 2 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced increase of cAMP accumulation pr...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 28nMAssay Description:Agonist activity at human histamine D2L receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recr...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recr...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.20nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazin...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.20nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazin...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 86nMAssay Description:Agonist activity at ARMS2-PK-tagged D2S receptor (unknown origin) transfected in HEK293 cells after 5 hrs by beta-arrestin assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293 cells cotransfected with Gqi5 protein assessed as [3H]IP3 accumulation after 120 mins by s...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 51nMAssay Description:Activity at pro-link-tagged D2S-ARMS2PK2 (unknown origin) expressed in HEK293 cells by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 1.62E+3nMAssay Description:Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 617nMAssay Description:Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 83nMAssay Description:Agonist activity at ARMS2-PK2-tagged human dopamine D2S receptor expressed in HEK293 cells co-expressing (EA)-tagged beta arrestin fusion protein ass...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 2.80E+3nMAssay Description:Intrinsic activity at human dopamine D2L receptor expressed in HEK293 cells co-transfected with Galphai2 assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 2.70E+3nMAssay Description:Intrinsic activity at human dopamine D2L receptor expressed in HEK293 cells co-transfected with Galpha0i assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Columbia University College of Physicians and Surgeons
Curated by ChEMBL
Affinity DataEC50: 2.30E+3nMAssay Description:Intrinsic activity at human dopamine D2S receptor expressed in HEK293 cells co-transfected with Galphai2 assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
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