Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'DNA-dependent protein kinase catalytic subunit' and Ligand = 'BDBM413460'
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))TBA
LigandPNGBDBM413460(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)copy SMILEScopy InChI
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V98C76US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))TBA
LigandPNGBDBM413460(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)copy SMILEScopy InChI
Affinity DataIC50: 0.158nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z18Z4PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))TBA
LigandPNGBDBM413460(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z18Z4PubMed