BindingDB PrimarySearch

Found 4 Enz. Inhib. hit(s) with Target = 'DNA-dependent protein kinase catalytic subunit' and Ligand = 'BDBM50098118'

BDBM50098118((2S,4R)-4-Mercapto-2-(2,4,5-trifluoro-benzyloxymet...)copy SMILEScopy InChI

IC50: 1.26E+3nMAssay Description:Inhibition of DNA dependent protein kinase isolated from HeLa cellsMore data for this Ligand-Target Pair

BDBM50098118((2S,4R)-4-Mercapto-2-(2,4,5-trifluoro-benzyloxymet...)copy SMILEScopy InChI

IC50: 1.30E+3nMAssay Description:Inhibitory activity against DNA-dependent protein kinase (DNA-PK) at 0.5 uMMore data for this Ligand-Target Pair

BDBM50098118((2S,4R)-4-Mercapto-2-(2,4,5-trifluoro-benzyloxymet...)copy SMILEScopy InChI

IC50: 4.30E+3nMAssay Description:Inhibition of DNA dependent protein kinase activity without hsp90 alpha proteinMore data for this Ligand-Target Pair

BDBM50098118((2S,4R)-4-Mercapto-2-(2,4,5-trifluoro-benzyloxymet...)copy SMILEScopy InChI

IC50: 1.00E+4nMAssay Description:Inhibition of DNA-dependent protein kinaseMore data for this Ligand-Target Pair

Targets 1 ▿
- DNA-dependent protein kinase catalytic subunit 4
Publications 4 ▿
- J Med Chem 48: 569-85 (2005) 1
- Bioorg Med Chem Lett 14: 6083-7 (2004) 1
- Bioorg Med Chem Lett 20: 3649-53 (2010) 1
- Bioorg Med Chem Lett 11: 909-13 (2001) 1
Institutions 4 ▿
- [The University, Newcastle University, University of Newcastle, Department of Molecular Oncogenesis] 1
- [The University, Newcastle University, University of Newcastle, Department of Molecular Oncogenesis] 1
- [The University, Newcastle University, University of Newcastle, Department of Molecular Oncogenesis] 1
- [The University, Newcastle University, University of Newcastle, Department of Molecular Oncogenesis] 1
Affinity: 1.3E+3 to 1.0E+4 nM▿
- IC50 4
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0