Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50036489'
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)copy SMILEScopy InChI
Affinity DataKi:  140nMAssay Description:Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JQ11PKPubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)copy SMILEScopy InChI
Affinity DataKi: >500nMAssay Description:Inhibitory compound against Wild-type human DHFR.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JQ11PKPubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JQ11PKPubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50036489(5-(2,5-Dimethoxy-phenylethynyl)-quinazoline-2,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against Pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JQ11PKPubMed