Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase 4' and Ligand = 'BDBM50253621'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50253621((S)-4-amino-5-((R)-2-boronopyrrolidin-1-yl)-5-oxop...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMAssay Description:Inhibition of human placental DPP4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM874WPubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50253621((S)-4-amino-5-((R)-2-boronopyrrolidin-1-yl)-5-oxop...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28W3J7ZUS Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50253621((S)-4-amino-5-((R)-2-boronopyrrolidin-1-yl)-5-oxop...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 2.0Assay Description:The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is eq...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ST7NJQUS Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50253621((S)-4-amino-5-((R)-2-boronopyrrolidin-1-yl)-5-oxop...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB77SRUS Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50253621((S)-4-amino-5-((R)-2-boronopyrrolidin-1-yl)-5-oxop...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMpH: 8.0Assay Description:The inhibitor solution is prepared by dissolving 3-5 mg of inhibitor in pH 2 solution (0.01 N HCl), such that the concentration of the solution is eq...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ST7NJQUS Patent