Found 10 Enz. Inhib. hit(s) with Target = 'Disintegrin and metalloproteinase domain-containing protein 17' and Ligand = 'BDBM50441213' TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of ADAM-17 in human L428 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 274nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 349nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of ADAM-17 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 5.64E+3nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 7.63E+3nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
San Raffaele Scientific Institute
Curated by ChEMBL
San Raffaele Scientific Institute
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
