Compile Data Set for Download or QSAR
Found 2 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM144636'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM144636(US8952036, Ex. 4)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to human GST-thrombin-tagged MDM2 ( 1 to 188 aa) assessed as inhibition of interaction with human p53 preincubated with compound for...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571DPWPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM144636(US8952036, Ex. 4)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Binding affinity to MDM2 in human SJSA1 cells assessed as induction of p21 gene level after 7 hrs by qRT-PCR assay in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571DPWPubMed