Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase XIAP' and Ligand = 'BDBM50393635'
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393635(CHEMBL2158604)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2Q3BPubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393635(CHEMBL2158604)copy SMILEScopy InChI
Affinity DataKi:  98nMAssay Description:Binding affinity to BIR3 domain of XIAP by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2Q3BPubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393635(CHEMBL2158604)copy SMILEScopy InChI
Affinity DataIC50: 17.7nMAssay Description:Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2Q3BPubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393635(CHEMBL2158604)copy SMILEScopy InChI
Affinity DataIC50: 289nMAssay Description:Binding affinity to BIR3 domain of XIAP by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2Q3BPubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393635(CHEMBL2158604)copy SMILEScopy InChI
Affinity DataEC50:  1.00E+3nMAssay Description:Antagonist activity at XIAP linker BIR2-BIR3 domain assessed as induction of caspase-9 activity using Z-LEHD as substrate preincubated for 15 mins me...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2Q3BPubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50393635(CHEMBL2158604)copy SMILEScopy InChI
Affinity DataEC50:  19nMAssay Description:Antagonist activity at XIAP linker BIR2-BIR3 domain assessed as induction of caspase-3 activity using Ac-DEVD-AFC as substrate preincubated for 15 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2Q3BPubMed