Compile Data Set for Download or QSAR
Found 9 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM50029687'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of EGFR Del ex19 mutant phosphorylation in human PC9 cells preincubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24Z9VPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24Z9VPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Neuroscience

LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21Z46Q0US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Neuroscience

LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21Z46Q0US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Neuroscience

LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21Z46Q0US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Neuroscience

LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 786nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells preincubated for 2 hrs followed by EGF stimulation measured after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24Z9VPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Neuroscience

LigandPNGBDBM50029687(CHEMBL3353412 | US10227342, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 7.86E+5nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2Z4CPubMed