Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Estrogen receptor' and Ligand = 'BDBM299162'
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM299162((6S,8R)-7-(2,2-difluoroethyl)-6-(5-(2-(3-(fluorome...)copy SMILES
Affinity DataIC50: 0.501nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9GDBPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM299162((6S,8R)-7-(2,2-difluoroethyl)-6-(5-(2-(3-(fluorome...)copy SMILES
Affinity DataIC50: 2.5nMAssay Description:Displacement of fluormone ES2 green reagent from human GST-tagged ERalpha LBD (282 to 595 residues) expressed in baculovirus infected insect cells in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9GDBPubMed
TargetEstrogen receptor(Homo sapiens (Human))TBA
LigandPNGBDBM299162((6S,8R)-7-(2,2-difluoroethyl)-6-(5-(2-(3-(fluorome...)copy SMILES
Affinity DataIC50: 5.90nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25B04KWUS Patent