Found 5 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 2-alpha kinase 3' and Ligand = 'BDBM50071957' TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human N-terminal His-tagged PERK expressed in Escherichia coli using AviTag C-terminal, N-terminal His-tagged eIF2alpha (3 to 315) as s...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of doxycycline-inducible T-REx-PERK-FLAG (unknown origin) autophosphorylation tranfected in human HT1080 cells after 1 hr by sandwich ELIS...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of GCN2 in amino acid starved human HT1080 cells assessed as inhibition of CHoP mRNA expression preincubated for 1 hr followed by 2 hrs in...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of PERK in human HT1080 cells assessed as inhibition of thapsigargin-induced CHoP mRNA expression preincubated for 1 hr followed by thapsi...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataEC50: 640nMAssay Description:Inhibition of PERK-mediated protein synthesis in human U2OS cells harboring thapsigargin-induced ER stress assessed as incorporation of L-azidohomoal...More data for this Ligand-Target Pair
