Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Excitatory amino acid transporter 3' and Ligand = 'BDBM50247191'
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))TBA
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human EAAT3 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2TQZPubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))TBA
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of human EAAT3 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2TQZPubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))TBA
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CR5TVNPubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))TBA
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of glutamate-induced depolarization in human human EAAT3 expressed in HEK293 cells by FMP assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M95FCPubMed