Compile Data Set for Download or QSAR
Found 7 Enz. Inhib. hit(s) with Target = 'Farnesyl pyrophosphate synthase' and Ligand = 'BDBM50226002'
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)copy SMILEScopy InChI
Affinity DataKi:  6.10E+4nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95B18PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)copy SMILEScopy InChI
Affinity DataKi:  9.75E+4nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95B18PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant FDPS (unknown origin) assessed as decrease in radiolabeld GGPP level using GPP and [14C]IPP as substrate treated with enzym...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61MZNPubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)copy SMILEScopy InChI
Affinity DataIC50: 2.54E+5nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27944DFPubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)copy SMILEScopy InChI
Affinity DataIC50: 2.54E+5nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95B18PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)copy SMILEScopy InChI
Affinity DataIC50: 4.67E+5nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95B18PubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21837FJPubMed