Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM286388'
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
PRINCIPIA BIOPHARMA, INC.

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85B83US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
PRINCIPIA BIOPHARMA, INC.

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
PRINCIPIA BIOPHARMA, INC.

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DB850WUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
PRINCIPIA BIOPHARMA, INC.

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX4DVZUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
PRINCIPIA BIOPHARMA, INC.

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XK8HKQUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
PRINCIPIA BIOPHARMA, INC.

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed