Found 12 Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 2' and Ligand = 'BDBM2579'
Affinity DataIC50: 0.757nMAssay Description:Inhibition of human FGFR2 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 1.80nMAssay Description:Inhibition of FGFR2 (unknown origin) after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human FGFR2 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of FGFR2 (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding constant for FGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Average Binding Constant for FGFR2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair