Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50165102'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)copy SMILEScopy InChI
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human glucocorticoid receptor alpha by displacement of [3H]-dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1CXXPubMed
TargetGlucocorticoid receptor(MOUSE)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)copy SMILEScopy InChI
Affinity DataEC50:  5nMAssay Description:GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 miceMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1CXXPubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)copy SMILEScopy InChI
Affinity DataEC50:  4.44E+3nMAssay Description:Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1CXXPubMed
TargetGlucocorticoid receptor(MOUSE)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)copy SMILEScopy InChI
Affinity DataEC50:  23nMAssay Description:Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1CXXPubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165102((S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5...)copy SMILEScopy InChI
Affinity DataEC50:  21nMAssay Description:GR-mediated transrepression of IL-6 in human A549 lung carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1CXXPubMed