Compile Data Set for Download or QSAR
Found 16 Enz. Inhib. hit(s) with Target = 'HIV-1 protease' and Ligand = 'BDBM8125'
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.00100nMAssay Description:Inhibition of HIV1 protease I50V, A71V mutant by FRET assayMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi: <0.00100nMAssay Description:Inhibition of HIV1 recombinant protease L10F/L19I/K20R/L33F/E35D/M36I/R41K/F53L/I54V/L63P/H69K/A71V/T74P/I84V/L89M/L90M/I93L mutant expressed in Esch...More data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.00400nMAssay Description:Inhibition of HIV1 protease L10I, G48V, I54V, L63P and V82A mutant by FRET assayMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.00430nMAssay Description:Inhibition of HIV1 recombinant protease A71V/V82T/I84V mutant expressed in Escherichia coli by spectrophotometric assayMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.0110nMAssay Description:Inhibition of HIV1 recombinant protease D30N/N88D mutant expressed in Escherichia coli by spectrophotometric assayMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.0270nMAssay Description:Inhibition of HIV1 protease L10I, L63P, A71V, G73S, I84V, L90M mutant by FRET assayMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.0320nMAssay Description:Inhibition of HIV1 recombinant protease M46I/A71V/V82T/I84V mutant expressed in Escherichia coli by spectrophotometric assayMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:Inhibition of HIV1 recombinant protease V32I/I47A mutant expressed in Escherichia coli by spectrophotometric assayMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.540nMAssay Description:Inhibition of HIV1 protease V82A mutantMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  0.560nMAssay Description:Inhibition of HIV1 protease I84V mutantMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Inhibition of HIV1 protease I50V mutantMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Inhibition of HIV1 protease D30N mutantMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  54nMAssay Description:Inhibition of HIV1 protease V32I mutant by enzyme inhibitionMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  180nMAssay Description:Inhibition of HIV1 protease V32I mutant by uncompetitive bindingMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Inhibition of HIV1 protease V32I mutant by competitive bindingMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
Nektar Therapeutics

US Patent
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Protease inhibitors (PI) are used to treat HIV infection by preventing viral assembly and maturation through the inhibition of HIV-1 protease activit...More data for this Ligand-Target Pair