Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Histamine H1 receptor' and Ligand = 'BDBM50240514'
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£t

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)copy SMILEScopy InChI
Affinity DataKi:  3.75nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7H6WPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£t

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17BZPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£t

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17BZPubMed
TargetHistamine H1 receptor(RAT)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)copy SMILEScopy InChI
Affinity DataIC50: 1.07nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17BZPubMed