Compile Data Set for Download or QSAR
Found 7 Enz. Inhib. hit(s) with Target = 'Histone deacetylase' and Ligand = 'BDBM29589'
TargetHistone deacetylase(Homo sapiens (Human))
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)copy SMILEScopy InChI
Affinity DataIC50: 0.830nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T155K0PubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Homo sapiens (Human))
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8WGCPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibition of HDAC1 in Plasmodium falciparum 3D7 nuclear extract using Ac-RGK(Ac)-AMC fluorogenic peptide as substrate preincubated for 1 hr followed...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD50D0PubMed
TargetHistone deacetylase(Homo sapiens (Human))
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of HDAC in human CAL27 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and further...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0KZ8PubMed
TargetHistone deacetylase(Homo sapiens (Human))
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Inhibition of HDAC in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and further...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0KZ8PubMed
TargetHistone deacetylase(Homo sapiens (Human))
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of HDAC in human HeLa cells using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ0C7PPubMed