Compile Data Set for Download or QSAR
Found 45 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 1' and Ligand = 'BDBM19130'
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataKi:  0.230nMAssay Description:Inhibition of recombinant HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8SCSPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 0.150nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC11N4PubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse liver HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WMTPubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z31Z9BPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2NQKPubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63MCKPubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C53K55PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human HDAC1 in presence of dithiothreitol by HDAC fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0TV8PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human HDAC1 using rhodamine as substrate after 1 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2319W8NPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC1 by in vitro deacetylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SKDPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046DKPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC815SPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC1 (unknown origin) after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6C11PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC1 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1R52PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0DT3PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ04XPPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2VF5PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP5413PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FQ9X48PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6JFVPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154GX2PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8KZJPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human recombinant HDAC1 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX9CG0PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 9.90nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1R6HPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human HDAC1 using Cbz-Lys(TFAc)-AMC as substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16FWPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human HDAC1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79CRKPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2Q8KPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human HDAC1 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84CXRPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of HDAC1 by fluorescent activity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028RZ0PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SF2VW0PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P55KRBPubMed
TargetHistone deacetylase 1(Mus musculus (Mouse))
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against histone deacetylases (HDAC1) prepared from mouse melanoma B16/BL6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8DC5PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human histone deacetylase 1 prepared from 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2222VJ6PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3Z3KPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 21nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8CT6PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61JWXPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M37XTPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3ZNRPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18ZCJPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 36.6nMAssay Description:Inhibition of human HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M1GPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4J77PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of HDAC1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K79C8PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22V2FG8PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9X0GPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£ de Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataEC50:  1.00E+3nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2VF5PubMed