Found 24 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 1' and Ligand = 'BDBM50439674' 
Affinity DataIC50: 19nMAssay Description:Inhibition of human HDAC1 preincubated for 15 mins followed by substrate addition by fluorescence-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells assessed as decrease ...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC1 (unknown origin) using FTS as substrate preincubated for 10 mins followed by substrate addition and shaken for 60 secs and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 58nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as subs...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 expressed in Sf9 cells using FTS as substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC1 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC1 (unknown origin) using FTS as substrate preincubated for 10 mins followed by substrate addition and shaken for 60 secsMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG-tagged HDAC1 expressed in sf9 cells preincubated for 5 mins followed by biotinylated H3K9...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as su...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant HDAC1 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
