Compile Data Set for Download or QSAR
Found 20 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 2' and Ligand = 'BDBM50439674'
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataKi:  204nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD15N3PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG-tagged HDAC2 expressed in Sf9 cells using FTS as substrate preincubated for 10 mins follo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2BT4PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of full length recombinant human C-terminal GST-tagged HDAC2 expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81GGBPubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H134MGPubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of HDAC2 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28917F9PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of human HDAC2 expressed in Sf9 cells using FTS as substrate preincubated for 10 mins followed by substrate addition and shaken for 60 sec...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76H9KPubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD15N3PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3XCCPubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79G8JPubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2639SXJUS Patent
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of HADC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280BWSPubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73JP3PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of human HDAC2 expressed in Sf9 insect cells using FTS as substrate preincubated for 10 mins followed by substrate addition and shaken for...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7KV7PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W09918US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ930NPubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T155H3PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 379nMAssay Description:Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26976Z8PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 379nMAssay Description:Inhibition of recombinant full length human HDAC2 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3QVSPubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)copy SMILEScopy InChI
Affinity DataIC50: 403nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD15N3PubMed