Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 3' and Ligand = 'BDBM50020897'
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant His6/GST-tagged human HDAC3 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21839VRPubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)copy SMILEScopy InChI
Affinity DataIC50: 108nMAssay Description:Inhibition of full length His6-tagged GST-fused recombinant human HDAC3 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2ZDZPubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40WRCPubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)copy SMILEScopy InChI
Affinity DataIC50: 262nMAssay Description:Enzyme activity of HDAC1,3 is determined using the substrate Ac-Lys-Tyr-Lys(Ac)-AMC while the enzyme activity of HDAC6 is assayed using the substrate...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7G3FUS Patent