BindingDB PrimarySearch

Found 18 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 4' and Ligand = 'BDBM50380399'

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

Ki: 5.38E+3nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged recombinant human HDAC4 (627 to 1084 residues) expressed in Baculovirus infected insect cel...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VX0KZ8PubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2639SXJUS Patent

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 1.10E+3nMT: 2°CAssay Description:Inhibition of HDAC4 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2XK8GWBPubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+3nMAssay Description:Inhibition of human full length recombinant HDAC4 using p53 (379 to 382 residues) Ac-LGK(TFA)-AMC as substrate preincubated for 5 to 10 mins followed...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2F76H9KPubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.67E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2Q81GFWUS Patent

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 4.27E+3nMAssay Description:Inhibitory activity against acetylcholinetransferase (AChE) enzymeMore data for this Ligand-Target Pair

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Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 5.00E+3nMMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2XD15N3PubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 5.00E+3nMAssay Description:Inhibition of HDAC4 (unknown origin) measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2MP574PPubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 1.73E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2Q23Z3WUS Patent

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2G73JP3PubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2D79G8JPubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC4 using fluorogenic trifluoroacetyl lysine as substrate by fluorescence assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2M90CCSPubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2028V2KPubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC4 (627 to 1085 residues) expressed in baculovirus expression system using AMC-labeled RHKKAc as substra...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2G44SQSPubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC4 (627 to 1085 residues) using fluorogenic acetyl-Lys(trifluoroacetyl)-AMC substrate incubated for 2 hr...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2B859QHPubMed

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMMore data for this Ligand-Target Pair

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Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q26D5RPKUS Patent

Histone deacetylase 4(Homo sapiens (Human))
Heinrich-Heine-University D£sseldorf

Curated by ChEMBL

BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)copy SMILEScopy InChI

IC50: 3.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q23R0RQNPubMed

Targets 1 ▿
- Histone deacetylase 4 18
Publications 10 ▿
- ACS Chem Biol 12: 254-264 (2017) 1
- US Patent US10456394 (2019) 1
- Bioorg Med Chem Lett 24: 5450-4 (2015) 1
- Bioorg Med Chem 27: (2019) 1
- US Patent US8748451 (2014) 1
- Eur J Med Chem 143: 1543-1552 (2018) 1
- Eur J Med Chem 135: 174-195 (2017) 1
- US Patent US9249087 (2016) 1
- Eur J Med Chem 152: 329-357 (2018) 1
- J Med Chem 56: 1772-6 (2013) 1
Institutions 10 ▿
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
- [THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium., TBA, Heinrich-Heine-University D£sseldorf, The Board of Trustees of The University of Illinois, Broad Institute of MIT and Harvard, Wayne State University, "G. D'Annunzio" University of Chieti-Pescara, University of Regensburg, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA] 1
Affinity: 30 to 3.0E+4 nM▿
- Ki 1
- IC50 17
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1