Compile Data Set for Download or QSAR
Found 9 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 5' and Ligand = 'BDBM50446481'
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataKi:  80nMAssay Description:Inhibition of human HDAC5 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76H9KPubMed
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataKi:  87nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC5 (656 to 1122 residues) expressed in baculovirus-infected insect cells using Boc-Lys(TFA)-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B33S0PubMed
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataIC50: 65.7nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2GT5QJ0US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataIC50: 108nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC5 (657 to 1123 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057HTZPubMed
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2611453PubMed
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataIC50: 263nMAssay Description:Inhibition of recombinant human HDAC5 using fluorogenic substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD145DPubMed
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataIC50: 333nMAssay Description:Inhibition of recombinant human C-terminal His-fusion tagged HDAC5 (657 to 1123 residues) expressed in baculovirus infected insect cells using fluoro...More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2KS6W0VPubMed
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataIC50: 354nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2G44TB8US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)copy SMILEScopy InChI
Affinity DataIC50: 990nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HH6NK6PubMed