Compile Data Set for Download or QSAR
Found 25 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 6' and Ligand = 'BDBM19410'
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human HDAC6 using pan-HDAC substrate incubated for 3 hrs by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76H9KPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 34nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8CB7PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 235nMMore data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 3.93E+3nMAssay Description:Inhibition of human recombinant HDAC6 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F47RTJPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 4.12E+3nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98CGBPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 7.35E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P27363PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 9.32E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028WGCPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16FWPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W957H9PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK99MZPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3BJ4PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells ZMAL as substrate incubated for 90 min...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8J5FPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged HDAC6 expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q24044PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length HDAC6 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154K5FPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC11N4PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of KDAC6 in human K562 cells using [3H]acetylated histone as substrate incubated for 10 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47MPPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human HDAC6 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057KBHPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3D1MPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M66QJPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant HDAC6 using p53 residues 379-382 (RHKKAc) as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N300XNPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant HDAC6 expressed in baculovirus using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate by Fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26W9FT0PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD15PJPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC6 by in vitro deacetylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SKDPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WMTPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed