Compile Data Set for Download or QSAR
Found 12 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 6' and Ligand = 'BDBM25150'
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B859V9PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 9.90nMAssay Description:Inhibition of recombinant human full length HDAC6 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154K5FPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 15nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Partial affinity towards Alpha-1 adrenergic receptor was assessed on rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:In brief, 10 μL of enzyme solution (HeLa nuclear extracts, HDAC1, HDAC4, HDAC6, HDAC8, HDAC11) was mixed with various concentrations of target c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50KSDPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125W99PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of full length recombinant human HDAC6 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumarin by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38VJ5PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 82nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280BWSPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 6.43E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1PCJPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataEC50:  82nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q2260PubMed