Compile Data Set for Download or QSAR
Found 11 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 8' and Ligand = 'BDBM25150'
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataKi:  22nMAssay Description:Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataKi:  25nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B859V9PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of HDAC8 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1PCJPubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human full length HDAC8 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154K5FPubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 157nMAssay Description:In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.More data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of His-tagged full length recombinant human HDAC8 expressed in baculovirus expression system assessed as release of 7-amino-4-methylcoumar...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38VJ5PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 353nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125W99PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 353nMAssay Description:In brief, 10 μL of enzyme solution (HeLa nuclear extracts, HDAC1, HDAC4, HDAC6, HDAC8, HDAC11) was mixed with various concentrations of target c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50KSDPubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 353nMAssay Description:To further ascertain HDAC isoform selectivity of 12m, we conducted enzymatic inhibitory assays against HDAC1 (class I), HDAC8 (class I), HDAC6 (class...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8Z69PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.53E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445R1PPubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataEC50:  216nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q2260PubMed