Found 10 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EHMT2' and Ligand = 'BDBM50442103' TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataKi: 3.70nMAssay Description:Non-competitive inhibition of lysine methyltransferase G9a (unknown origin) using SAM as substrate by Michaelis-Menten kinetic assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
In DepthDetails
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of lysine methyltransferase G9a in human PANC1 cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell Western...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of lysine methyltransferase G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell We...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of lysine methyltransferase G9a in human PC3 cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell Western a...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of lysine methyltransferase G9a in human U2OS cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell Western ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University of North Carolina at Chapel Hill
Curated by ChEMBL
University of North Carolina at Chapel Hill
Curated by ChEMBL
