Found 2 Enz. Inhib. hit(s) with Target = 'Isocitrate dehydrogenase [NADP] cytoplasmic' and Ligand = 'BDBM279855' TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Agios Pharmaceuticals, Inc.
Curated by ChEMBL
Agios Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
3D Structure (crystal)TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Agios Pharmaceuticals, Inc.
Curated by ChEMBL
Agios Pharmaceuticals, Inc.
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of full length C-terminal His8 tagged IDH1 R132H mutant (1 to 414 residues) (unknown origin) homodimer expressed in Escherichia coli BE3 c...More data for this Ligand-Target Pair
