Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]' and Ligand = 'BDBM390460'
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390460(US10442772, Example 2-123-2 | US9957235, 2-123 | U...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390460(US10442772, Example 2-123-2 | US9957235, 2-123 | U...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZW7US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Fujisawa Pharmaceutical Co. Ltd

LigandPNGBDBM390460(US10442772, Example 2-123-2 | US9957235, 2-123 | U...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:The biochemical reactions were performed at 32° C. in 384-well plates using a reaction volume of 41 μL and the following assay buffer conditions...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21R6SVHUS Patent