BindingDB PrimarySearch

Found 2 Enz. Inhib. hit(s) with Target = 'L-lactate dehydrogenase A chain' and Ligand = 'BDBM50250689'

L-lactate dehydrogenase A chain(Homo sapiens (Human))
National Center for Advancing Translational Sciences

Curated by ChEMBL

BDBM50250689(CHEMBL4069726 | US10961200, Compound 47 | US112479...)copy SMILEScopy InChI

IC50: 42nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair

L-lactate dehydrogenase A chain(Homo sapiens (Human))
National Center for Advancing Translational Sciences

Curated by ChEMBL

BDBM50250689(CHEMBL4069726 | US10961200, Compound 47 | US112479...)copy SMILEScopy InChI

IC50: 100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair

Targets 1 ▿
- L-lactate dehydrogenase A chain 2
Publications 2 ▿
- US Patent US10961200 (2021) 1
- J Med Chem 60: 9184-9204 (2017) 1
Institutions 2 ▿
- [National Center for Advancing Translational Sciences, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; THE UAB RESEARCH FOUNDATION; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA] 1
- [National Center for Advancing Translational Sciences, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; THE UAB RESEARCH FOUNDATION; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA] 1
Affinity: 42 to 1.0E+2 nM▿
- IC50 2
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0