Compile Data Set for Download or QSAR
Found 8 Enz. Inhib. hit(s) with Target = 'L-lactate dehydrogenase A chain' and Ligand = 'BDBM86137'
TargetL-lactate dehydrogenase A chain(Rattus norvegicus (Rat))
AstraZeneca

LigandPNGBDBM86137(LDHA Inhibitor, 33)copy SMILEScopy InChI
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:Enzyme assay using lactate dehydrogenase A (LDHA).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9896PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))TBA
LigandPNGBDBM86137(LDHA Inhibitor, 33)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V128MVPubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))TBA
LigandPNGBDBM86137(LDHA Inhibitor, 33)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5J28PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))TBA
LigandPNGBDBM86137(LDHA Inhibitor, 33)copy SMILEScopy InChI
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5J28PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))TBA
LigandPNGBDBM86137(LDHA Inhibitor, 33)copy SMILEScopy InChI
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of LDH in human MIAPaCa2 cells assessed as reduction in lactate production preincubated for 2 hrs measured after 30 mins by high throughpu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5J28PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))TBA
LigandPNGBDBM86137(LDHA Inhibitor, 33)copy SMILEScopy InChI
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of LDH in human A673 cells assessed as reduction in lactate production preincubated for 2 hrs measured after 30 mins by high throughput fl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5J28PubMed
TargetL-lactate dehydrogenase A chain(Rattus norvegicus (Rat))
AstraZeneca

LigandPNGBDBM86137(LDHA Inhibitor, 33)copy SMILEScopy InChI
Affinity DataKd:  93nMpH: 7.4Assay Description:A BIAcore 3000 or a BIAcore S51 instrument (GE Healthcare) was used to detect binding interactions using a direct binding assay format.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9896PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))TBA
LigandPNGBDBM86137(LDHA Inhibitor, 33)copy SMILEScopy InChI
Affinity DataEC50:  1.60E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5J28PubMed