Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Leukotriene A-4 hydrolase' and Ligand = 'BDBM24220'
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development, LLC

Curated by ChEMBL
LigandPNGBDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 9.70nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development, LLC

Curated by ChEMBL
LigandPNGBDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB22CXPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development, LLC

Curated by ChEMBL
LigandPNGBDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 365nMAssay Description:Inhibition of LTA4H in human whole blood assessed as decrease in LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed