Compile Data Set for Download or QSAR
Found 11 Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM254603'
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZTBUS Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZTBUS Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataKi:  550nM ΔG°:  -35.7kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN93SBUS Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB78CSPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant N-terminal His/GST-tagged LSD1 (172 to 852 residues) expressed in baculovirus infected insect cells using biotin-labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474DCPPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZTBUS Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23X8BBHPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZS2ZTBUS Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataIC50: 292nMpH: 7.4 T: 2°CAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN93SBUS Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataEC50: >20nMAssay Description:Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474DCPPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics S.A.

US Patent
LigandPNGBDBM254603(US10214477, Example 5 | US9469597, 4 | US9670136, ...)copy SMILEScopy InChI
Affinity DataEC50:  0.950nMAssay Description:Inhibition of LSD1 in human MV-4-11 cells assessed as increase in CD86 mRNA expression after 10 days by SYBR Green dye-bsed RT-qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474DCPPubMed