Found 5 Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM301063' TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene Quanticel Research, Inc.
US Patent
Celgene Quanticel Research, Inc.
US Patent
Affinity DataIC50: 10nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene Quanticel Research, Inc.
US Patent
Celgene Quanticel Research, Inc.
US Patent
Affinity DataIC50: 100nMAssay Description:Inhibition of full length human LSD1 expressed in Escherichia coli using H3K4me1-biotin labeled peptide as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene Quanticel Research, Inc.
US Patent
Celgene Quanticel Research, Inc.
US Patent
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli using Histone H3(1 to 21)K4(Me1) biotin...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene Quanticel Research, Inc.
US Patent
Celgene Quanticel Research, Inc.
US Patent
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as upregulation of CD86 levels by ELISAMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Celgene Quanticel Research, Inc.
US Patent
Celgene Quanticel Research, Inc.
US Patent
Affinity DataKd: 42nMAssay Description:Reversible inhibition of human recombinant N-terminal truncated LSD1 (151 to 852 residues) expressed in Escherichia coli by SPR analysisMore data for this Ligand-Target Pair
