Compile Data Set for Download or QSAR
Found 24 Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM50240772'
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition of human LSD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38SWTPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataKi:  2.50E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataKi:  2.43E+5nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9P6HPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataKi:  2.43E+5nMAssay Description:Inhibition of N-terminal 6histidine-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21(DE3) cells assessed as reduction in Peroxide prod...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7DTBPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataKi:  3.57E+5nMAssay Description:Irreversible inhibition of LSD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23X870SPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant His-tagged LSD1 (171 to 836) assessed as hydrogen peroxide formation after 5 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028VHDPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 4.64E+3nMAssay Description:Inhibition of human N-terminal GST-tagged LSD1 isoform2 (158 to end residues) expressed in Escherichia coli using methylated peptide as substrate pre...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6GG3PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli using methylated H3K4peptide as substrate incubated for 15 mins prior to substrate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ12QFPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of human recombinant LSD1 incubated for 30 mins using H3K4me2 peptide substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N83Q5PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of LSD1 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8J40PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant KDM1A using H3K4me2 and ADHP substrate assessed as inhibition of resorufin formation by peroxidase coupled enzyme ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP5559PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of recombinant human LSD1 (172 to 852 residues) using biotin-labelled H3K4me2 (1 to 24 residues) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2TB1PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.29E+4nMAssay Description:Inhibition of recombinant N-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli expression system using ART-K(Me1)-QTARKSTGGKAPRK...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22N55VZPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.37E+4nMAssay Description:Inhibition of recombinant full length LSD1 (unknown origin) transfected in Escherichia coli BL21 (DE) using H3K4me2 as substrate by flourescence base...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23X8BFVPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29P30CCUS Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.63E+4nMAssay Description:Inhibition of recombinant full length LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) using H3K4me2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3TX0PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of LSD1 (unknown origin) incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27SCPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of human recombinant LSD1 (157 to 852 aa) expressed in Escherichia coli BL21(DE) using H3K4me2 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD1333PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of recombinant LSD1 (157 to 852) (unknown origin) transfected in Escherichia coli BL21(DE) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC12CZPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.85E+4nMAssay Description:Inhibition of recombinant human LSD1 (157 to 852 residues) expressed in Escherichia coli BL21 (DE) cells using H3K4me2 substrate incubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22F7S37PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 3.97E+4nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60QJ7PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataIC50: 8.07E+4nMAssay Description:Inhibition of recombinant human LSD1 using H3K4me2 peptide as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3GX3PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataKd:  1.01E+5nMAssay Description:Binding affinity to recombinant LSD1(unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC12CZPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-p...)copy SMILEScopy InChI
Affinity DataKd:  4.63E+4nMAssay Description:Binding affinity to human recombinant LSD1 (157 to 852 aa) expressed in Escherichia coli BL21(DE) by microscale thermophoresis assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD1333PubMed