Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM50078114'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)copy SMILEScopy InChI
Affinity DataKi:  7.73E+3nM IC50: 1.20E+4nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GG7US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)copy SMILEScopy InChI
Affinity DataKi:  5.30E+4nM ΔG°:  -25.4kJ/mole IC50: 9.49E+3nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX77STPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)copy SMILEScopy InChI
Affinity DataKi:  1.40E+5nMMore data for this Ligand-Target Pair
In DepthDetails
TargetLysosomal acid glucosylceramidase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Compound was tested for inhibitory activity against beta-glucocerebrosidase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3FV3
TargetLysosomal acid glucosylceramidase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)copy SMILEScopy InChI
Affinity DataIC50: 8.90E+3nMAssay Description:Specific inhibitory activity against Glucosylceramidase in mouse liverMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22J6B1MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM

US Patent
LigandPNGBDBM50078114((1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,...)copy SMILEScopy InChI
Affinity DataIC50: 9.49E+3nMMore data for this Ligand-Target Pair
In DepthDetails