Compile Data Set for Download or QSAR
Found 9 Enz. Inhib. hit(s) with Target = 'Lysosomal alpha-glucosidase' and Ligand = 'BDBM18355'
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataKi:  200nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3HVMPubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataKi:  3.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736QZBPubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M908TCPubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VTXPubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of rat liver lysosomal alpha-glucosidase using p-nitrophenyl alpha-D-glucopyranoside as substrate by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1P1CPubMed
TargetLysosomal alpha-glucosidase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of maltase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1X5HPubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))TBA
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataIC50: 1.58E+5nMAssay Description:Inhibition of recombinant human GAA by UV-visible spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1P1CPubMed
TargetLysosomal alpha-glucosidase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)copy SMILEScopy InChI
Affinity DataEC50:  1.18E+4nMpH: 4.0Assay Description:Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T43RWBUS Patent