Compile Data Set for Download or QSAR
Found 24 Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 4' and Ligand = 'BDBM50142895'
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  120nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I125A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  151nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268F expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  160nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z1527PubMed
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  160nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10GGPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  160nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human wild type MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I291A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  560nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287F expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  870nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  890nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  1.82E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184L expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  2.99E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I129A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 103nMAssay Description:Antagonist activity at MC4R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3F54PubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Antagonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human MC4R expressed in CHO cells assessed as inhibition of alpha-MSH-induced cAMP production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3F54PubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 355nMAssay Description:Antagonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Antagonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 708nMAssay Description:Antagonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.03E+3nMAssay Description:Antagonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.71E+3nMAssay Description:Antagonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.86E+3nMAssay Description:Antagonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+3nMAssay Description:Antagonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 3.77E+3nMAssay Description:Antagonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 6.19E+3nMAssay Description:Antagonist activity at the mutant MC4R I125L expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D21ZCXPubMed