Found 22 Enz. Inhib. hit(s) with Target = 'Melatonin receptor type 1B' and Ligand = 'BDBM50035179' TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.0420nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.210nMAssay Description:Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cells incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.210nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.270nMAssay Description:Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as ra...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.270nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataKi: 0.450nMAssay Description:Binding affinity for melatonin receptor type 1B, expressed in HEK-293 cells (2-[125I]-Iodomelatonin is used as radioligand)More data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataEC50: 0.210nMAssay Description:Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataEC50: 0.180nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataEC50: 0.180nMAssay Description:Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataEC50: 0.100nMAssay Description:Agonist potency determined by [35S]-GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development, Ltd.
Curated by PDSP Ki Database
Affinity DataEC50: 0.180nMAssay Description:Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
