Compile Data Set for Download or QSAR
Found 8 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50094841'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataKi:  47.7nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu2 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  2.64E+3nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  153nMAssay Description:Agonist activity at human mGlu2 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  154nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  29.4nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  29.4nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated in presence of 30 microM glutamic acidMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed