BindingDB PrimarySearch

Found 2 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM5718'

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Aventis Pharma Deutschland GmbH

Curated by ChEMBL

BDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)copy SMILEScopy InChI

IC50: 7.00E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase 1 (MAPK-ERK2)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details
BindingDB Entry DOI: 10.7270/Q25B01SBPubMed PDB

3D Structure (crystal)

Mitogen-activated protein kinase 1(Rattus norvegicus (rat))
University of Texas Southwestern Medical Center at Dallas

BDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)copy SMILEScopy InChI

IC50: 2.70E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Purchase CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2XP7351PubMed DrugBank
PDB

3D Structure (crystal)