Compile Data Set for Download or QSAR
Found 18 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit alpha-7' and Ligand = 'BDBM10759'
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataKi:  501nMAssay Description:Displacement of [3H]epibatidine from chimeric human alpha7-5-HT3A receptor expressed in HEK293 cells after 2 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73HMSPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataKi:  7.94E+3nMAssay Description:Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cells after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN09BHPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99PVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99PVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataKi:  1.70E+5nMAssay Description:Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4KSTPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  2.30E+5nMAssay Description:Effective concentration that causes inhibition of alpha-7 nAChR, was determined. Values are expressed as EC50 +/- SEM.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2028S36PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  1.80E+5nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  4.00E+3nMAssay Description:Antagonist activity at human alpha7nAChR co-expressed with human Ric3 in tsA201 cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67HRCPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  4.00E+3nMAssay Description:Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67HRCPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  3.12E+3nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4DJ7PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  8.30E+4nMAssay Description:Agonist activity at human alpha-7 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S4DPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  1.10E+5nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in Xenopus oocytes at -60 mV holding potential by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R49TF0PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  6.90E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte in presence of 6 uM (S)-ethyl 1-(2-cyanoethyl)pyrrolidine-2-carboxylat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RB9PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  8.70E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RB9PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  2.05E+5nMAssay Description:Agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents treated for 3 to 4 se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC058KPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  2.09E+5nMAssay Description:Agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents treated for 3 to 4 se...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QC058KPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  1.28E+5nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN46RRPubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)copy SMILEScopy InChI
Affinity DataEC50:  1.55E+5nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8TH9PubMed