Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase' and Ligand = 'BDBM50435784'
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50435784(CHEMBL2393190 | US11279687, Compound 134)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7DN3US Patent
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50435784(CHEMBL2393190 | US11279687, Compound 134)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of NAMPT (unknown origin) assessed as NAM conversion to NMN preincubated for 15 mins prior to substrate addition measured after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5H1DPubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50435784(CHEMBL2393190 | US11279687, Compound 134)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7DN3US Patent