Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Nitric oxide synthase, endothelial' and Ligand = 'BDBM50014713'
TargetNitric oxide synthase, endothelial(Rattus norvegicus)
Northwestern University

US Patent
LigandPNGBDBM50014713(CHEMBL3262022 | US10759791, Compound 6 | US9951014...)copy SMILEScopy InChI
Affinity DataKi:  35nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1PZGUS Patent
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Astex

LigandPNGBDBM50014713(CHEMBL3262022 | US10759791, Compound 6 | US9951014...)copy SMILEScopy InChI
Affinity DataKi:  4.77E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N83G1US Patent
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50014713(CHEMBL3262022 | US10759791, Compound 6 | US9951014...)copy SMILEScopy InChI
Affinity DataKi:  4.77E+3nMAssay Description:Inhibition of purified bovine eNOS assessed as inhibition of nitric oxide-mediated oxidation of hemoglobin-A by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6S26PubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50014713(CHEMBL3262022 | US10759791, Compound 6 | US9951014...)copy SMILEScopy InChI
Affinity DataKi:  4.77E+3nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1PZGUS Patent
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Astex

LigandPNGBDBM50014713(CHEMBL3262022 | US10759791, Compound 6 | US9951014...)copy SMILEScopy InChI
Affinity DataKi:  6.62E+3nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1PZGUS Patent
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50014713(CHEMBL3262022 | US10759791, Compound 6 | US9951014...)copy SMILEScopy InChI
Affinity DataKi:  1.77E+4nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1PZGUS Patent